Ben Bikman

These drugs are decreasing the body's demand for insulin rather than supplying more of it.

Par gamma is what we call the master regulator of adipogenesis.

In type 1 diabetes, intensive glycemic control does in fact help prevent neuropathy... In type two diabetes, the same intervention doesn't really move the needle.

You don't just release insulin when you eat. You may release insulin when you think about food. That signal comes from your brain through the vagus nerve straight to your pancreas.

About 80% of the glucose clearance after a meal is going into the muscle.

GLP-1 in a physiological context is an insulin-sparing hormone. It's a brake on postprandial insulin, not an accelerant as it's often viewed.

Your brain is extraordinarily energy hungry. It only weighs about 2% of your body mass, but it consumes about 20% of your calories at resting.

When LDL binds LPS, it actually neutralizes it. It blunts the ability of LPS to go activate immune receptors and trigger inflammation. That's a fact that's well-established.

When Ivermectin gets dismissed as just a horse dewormer, what we're really seeing, I think, is a rhetorical slight of hand that strips away the drug's entire humanitarian history and Nobel Prize-winning science to make i

Sleep is not passive downtime for your body. It's a period of active hormonal regulation, cellular repair, and some metabolic bookkeeping.

The plaques were not just a marker of the disease, but as the theory went, the plaques are the disease.

It's not how fat you are, it's how big your individual fat cells are that predicts your metabolic health.

Your muscles are talking. They are sending these messages to other tissues and cell types throughout your body and doing so with these remarkable nano-sized packages that are called extracellular vesicles.

Think of NAD as a rechargeable battery in your cells.

Take a drug that damages your gonads potentially beyond repair. It disrupts your sex hormone production. It impairs your fertility. And you do it all on the hope that it might extend your lifespan based on some studies i

Nicotine when administered alone has what they called poor reinforcing effects.

The insulin-to-glucagon ratio is arguably one of the most important determinants of whether your body is storing fat or burning it.

Your gut barrier is your metabolic gatekeeper. Keep it strong and you'll very likely keep metabolic and other problems at bay.

If female menopause is like a warehouse running out of inventory, male menopause is like a factory that keeps running but slowly produces less and less of the product each year.

ALA is essentially metabolically useless for the fat burning and the muscle building effects that we're discussing here.