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Episode
10 Healthiest Foods You MUST Have In Your Diet
~37 min
Episode Brief·YouTube

10 Healthiest Foods You MUST Have In Your Diet

Sten Ekberg
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TL;DR

The four things you'd lose by not watching

4 items

TL;DR

The four things you'd lose by not watching

4 items
1

Sten Ekberg reframes nutrition as feeding two distinct biological systems: human cells (protein, fat, vitamins, minerals) and the gut microbiome (fiber, polyphenols, resistant starch) — each has a completely different set of requirements that the standard food pyramid ignores.

2

The top 10 foods he recommends are: fermented dairy/vegetables, cruciferous veggies, leafy greens, berries, avocado/olives/olive oil, nuts/seeds, whole eggs, fatty fish (sardines, mackerel, salmon), organ meats (liver, heart, kidney), and grass-fed beef with all parts including connective tissue.

3

Whole eggs are a critical source of choline for cell membranes and brain health, fatty fish provide DHA for retina and synaptic plasticity, fermented foods seed the gut with probiotics and produce butyrate to maintain gut integrity, and cruciferous vegetables activate the NRF2 master antioxidant pathway (catalase neutralizes 6 million free radicals per minute).

4

Grains, seed oils, and sugar — the base of the food pyramid — have no essential nutrients and are primarily empty calories that disrupt metabolic health; insulin-resistant individuals are functionally carbohydrate intolerant and should avoid them.

Protocols

Concrete recipes — what, when, how much, and why

7 items

Eat fermented foods daily (yogurt, kefir, sauerkraut) to seed the gut with probiotics

WhatConsume fermented dairy (yogurt, kefir) and fermented vegetables (sauerkraut, kimchi, or any fermented veggie) regularly to introduce live bacterial species that colonize the gut, compete with pathogens, and promote postbiotic production.
WhenDaily, as a regular part of meals; can be a side or condiment.
DoseNot specified exactly; a few tablespoons of yogurt/kefir or a serving of sauerkraut/kimchi daily is implied. Making yogurt at home for 48–60 hours maximizes bacteria and eliminates lactose.
For whomEveryone, especially those with gut dysbiosis, insulin resistance, or inflammation. Avoid commercial pickled products (vinegar-based) that lack live bacteria.
WhyFermented foods provide probiotics (Lactobacillus, Bifidobacterium, beneficial yeasts) that inhibit pathogenic opportunistic bacteria; they also contain prebiotics and are predigested, reducing anti-nutrients; gut bacteria produce butyrate and other postbiotics that feed colonocytes and maintain tight gut junctions to prevent leaky gut.
CaveatsCommercial yogurts may be pasteurized or high in sugar; make your own for maximum benefit. People with severe histamine intolerance may need to introduce slowly. Not all fermented foods are equal — pickling (vinegar) does not provide probiotics.

Ekberg emphasizes that fermentation is a three-pronged gut strategy: (1) probiotics directly inoculate the gut with colonizing species like Bifidobacterium, which can set up long-term residence; (2) the fibrous vegetable matter in ferments like sauerkraut serves as prebiotic food for existing and incoming bacteria; (3) this microbial fermentation produces postbiotics — particularly butyrate — that fuel the enterocytes lining the gut and tighten the intercellular junctions. When junctions are compromised, lipopolysaccharides (LPS) from pathogenic bacteria leak into the blood, causing systemic inflammation that can manifest as anxiety, depression, and metabolic chaos. He highlights that homemade yogurt run for 48–60 hours eats up virtually all lactose, making it safe for lactose-intolerant people, and dramatically increases the live bacterial count and diversity. Kefir is even more complex, with many more bacterial strains and beneficial yeasts. Fermentation also neutralizes problematic plant compounds like phytates and lectins, so even those sensitive to raw veggies may tolerate fermented versions.

Mechanism

Live bacteria from yogurt (Lactobacillus, Bifidobacterium) and kefir (additional strains and yeasts) compete for adhesion sites and nutrients in the gut, suppressing pathogenic species. Some are colonizers that establish permanent residence. The bacteria ferment prebiotic fibers and polyphenols, producing short-chain fatty acids, notably butyrate. Butyrate is the primary fuel for colonocytes, strengthens the intestinal tight junctions via protein synthesis, and thus prevents LPS translocation. The reduction in luminal pH also inhibits pathogen growth. Lactose is broken down during the long fermentation, and anti-nutrients like lectins are partially degraded.

Personal experience

I personally make yogurt at home using a machine, letting it ferment for 48 to 60 hours. It becomes much more sour, loaded with beneficial bacteria, and virtually lactose-free.

Fermentation is mankind's oldest form of preservation. And not just does it preserve it, but in case of yogurt and kefir, what they provide is probiotics. And that means that they have live bacterial species that can seed and diversify the bacterial flora that we have in our guts.

Also said
“Because in doing your own, you can let the machine run for much, much longer. I run my yogurt for 48 to 60 hours and it gets much more sour and I get much more of the beneficial bacteria. Plus, they eat up all the lactose. So, there's very, very little sugar left.”— Details the practical, personalized method to maximize benefits and eliminate lactose.
“And also fermentation actually predigests a lot of the antiutrients. A lot of the things that people are sensitive to in plants like phitates and lectins, once we ferment them, a lot of that stuff goes away.”— Explains the additional benefit of reducing plant-derived irritants.

Eat cruciferous vegetables (broccoli, sprouts, cabbage) to activate the NRF2 master antioxidant switch

WhatRegularly include cruciferous vegetables — broccoli, broccoli sprouts, Brussels sprouts, cabbage, cauliflower, arugula — to provide sulforaphane, which turns on the NRF2 pathway and triggers the body's own potent antioxidant and detoxification enzymes.
WhenSeveral times per week, as part of meals; raw or lightly cooked is best to preserve sulforaphane formation.
DoseNo specific dose given; incorporate as a staple vegetable group.
For whomEveryone, especially those seeking to reduce oxidative stress and inflammation. No specific contraindications mentioned, but those with gut sensitivity may benefit from cooking or fermenting.
WhySulforaphane activates NRF2, a transcription factor that upregulates glutathione, catalase (neutralizes 6 million free radicals/min), and superoxide dismutases — endogenous antioxidants that vastly outperform dietary vitamin C. Crucifers also provide fermentable fiber for butyrate production and support mucus formation for gut protection.
CaveatsHe does not discuss thyroid concerns; the video focuses on the antioxidant and gut benefits. The sulforaphane is formed when the vegetable is cut/chewed; over-cooking may reduce it.

Ekberg directly challenges the popular narrative that “antioxidant-rich fruits and vegetables are good because you get a bunch of antioxidants.” He argues that dietary antioxidants like vitamin C are a drop in the ocean compared to the endogenous antioxidants the body can produce when NRF2 is activated. He explains that while vitamin C donates two electrons and is then spent, catalase is an enzyme that recycles and continuously neutralizes millions of free radicals per minute. The cruciferous vegetables also serve the gut by providing fermentable fiber that turns into butyrate, and they contribute to mucus formation via specific compounds, further strengthening the gut barrier. This dual action — supporting both the human detoxification system and the gut — is why they are essential. He places this group firmly in the ‘feed the gut’ category but notes it indirectly feeds the human by reducing oxidative damage.

Mechanism

Sulforaphane, an isothiocyanate formed when glucoraphanin in crucifers contacts the enzyme myrosinase during chewing/chopping, activates the Nrf2-ARE pathway. Nrf2 translocates to the nucleus and binds to antioxidant response elements promoting transcription of phase II detoxification enzymes (glutathione S-transferases, NAD(P)H quinone oxidoreductase) and antioxidant enzymes (catalase, superoxide dismutase, heme oxygenase-1). These enzymes neutralize reactive oxygen species and xenobiotics far more efficiently than any dietary antioxidant molecule can. The fiber also undergoes bacterial fermentation to butyrate, which inhibits HDACs and further reinforces anti-inflammatory signaling.

This is a chemical compound that activates what's called NRF2, which is kind of a master switch for your body's cleanup defenses. So, this master switch will turn on glutathione and catalase and super oxide dismutates, which are your body's antioxidants and cleanup crew.

Also said
“Dietary antioxidants don't even come close. They're not in the same universe of comparison. They're negligible in comparison. So vitamin C, for example, it can donate two electrons and neutralize a free radical. Then it's done. Whereas for example this catalase it can it's an enzyme and it will neutralize six million free radicals per minute and keep going.”— Quantifies the dramatic superiority of endogenous enzymatic antioxidants.

Eat whole eggs (yolk + white) as a choline-rich, high-value protein source

WhatConsume whole eggs — do not discard yolks — to obtain choline for cell membranes, neurotransmitter production, liver fat export, and to get lutein/zeaxanthin for retinal and brain protection.
WhenRegularly, as a meal component; can be daily for most people.
DoseNo specific number given; eggs are presented as a staple 'high quality protein' food.
For whomEveryone, particularly those concerned with liver health, cognitive function, or eye health. Individuals with familial hypercholesterolemia may need to monitor intake, but dietary cholesterol fears are largely outdated.
WhyCholine is used to make phosphatidylcholine (major cell membrane component), acetylcholine (neurotransmitter), and VLDL particles to export fat from the liver, preventing non-alcoholic fatty liver disease. Eggs contain lutein and zeaxanthin that are incorporated into brain and retina, reducing macular degeneration risk. The combined white and yolk provide a complete amino acid profile with the highest protein score among foods.
CaveatsAvoid egg white cartons that discard the nutrient-dense yolk. No mention of allergen concerns.

Ekberg is passionate about the yolk, saying he 'cries inside' when he sees egg white cartons. He explains that choline is not just a peripheral nutrient; it is structurally required for cell membranes (phosphatidylcholine is the second largest component after cholesterol), for liver function (VLDL assembly to export triglycerides; virtually every fatty liver case shows choline deficiency), and for the neurotransmitter acetylcholine (signaling, muscle contraction). The lutein and zeaxanthin in yolks are carotenoids that selectively accumulate in the retina and brain, protecting against oxidative damage and specifically reducing macular degeneration. He relates a personal story: his father developed macular degeneration, lost central vision, stopped reading and watching TV, became inactive, and over time that inactivity accelerated physical degeneration — implying that preserving eye health is a matter of preserving overall vitality. Eggs also have the highest biological value protein when yolk and white are eaten together, creating an ideal amino acid ratio.

Mechanism

Choline is a precursor for phosphatidylcholine synthesis via the CDP-choline pathway, essential for cell membrane integrity. In the liver, phosphatidylcholine is required to assemble very-low-density lipoproteins (VLDLs) that package and export triglycerides; deficiency leads to hepatic steatosis. Choline also donates methyl groups for DNA methylation via betaine metabolism. Acetylcholine synthesis depends on choline acetyltransferase. Lutein and zeaxanthin are xanthophylls that cross the blood-retinal barrier, concentrated in the macula, where they filter high-energy blue light and quench singlet oxygen, reducing oxidative stress that triggers age-related macular degeneration.

Personal experience

My dad got macular degeneration and that's basically what killed him because once he couldn't see very well he lost his central vision... as his vision went he couldn't watch TV. He couldn't read books, and over time he just stopped being active. And when you stop being active, your body starts degenerating much, much faster.

Please please don't separate the egg the yolk from the white and I cry inside every time I see this little package in the store with egg whites. It is such a waste.

Also said
“In fact, they have found that virtually every case of fatty liver has a deficiency in choline.”— Links choline deficiency directly to fatty liver disease, underscoring the importance of whole eggs.

Eat fatty fish (sardines, mackerel, wild salmon, herring) for EPA and DHA

WhatInclude small, cold-water fatty fish like sardines, mackerel, herring, and wild-caught salmon in your diet to supply high levels of EPA and DHA omega-3s, supporting anti-inflammatory pathways, brain health, retinal integrity, and synaptic plasticity.
WhenAt least a few times per week; sardines are always wild and low in contaminants.
DoseNo daily gram amount; regular consumption of fatty fish as a protein/fat source.
For whomAll individuals, especially those with inflammatory conditions, cognitive decline risk, or vision concerns. Even farm-raised salmon is better than processed junk, but wild is superior.
WhyEPA downregulates inflammatory signaling (COX pathways), reducing cardiovascular risk. DHA is the dominant fatty acid in brain and retina (up to 50% of retina); it ensures membrane fluidity, facilitates new synaptic connections (plasticity), and is essential for visual processing. Wild fish have a better DHA/EPA ratio and lower contaminants.
CaveatsAvoid large predatory fish high in mercury; stick to sardines, mackerel, herring. Eat a variety, and don't over-rely on a single source.

Ekberg positions fatty fish as the richest natural source of the long-chain omega-3s, noting that while grass-fed beef and eggs contain some, they don't compare. The EPA primarily acts on inflammatory pathways, helping to quell the systemic inflammation at the root of heart disease. DHA, on the other hand, is structurally incorporated into neuronal and retinal cell membranes, enhancing their fluidity and allowing neurotransmitter receptors to function optimally. This is why DHA is linked to learning, memory, and visual acuity. He specifically warns against large fish like tuna due to mercury accumulation, but says sardines are almost always wild-caught and small, thus low in toxins. He gives permission to eat farm-raised salmon if that's the only option, because it's still far better than processed foods, but strongly encourages seeking out wild. The objective is to achieve a tissue ratio of omega-6 to omega-3 that is not 15–20:1 as in most modern diets.

Mechanism

EPA and DHA are incorporated into cell membrane phospholipids, displacing arachidonic acid and reducing substrate for pro-inflammatory eicosanoids (prostaglandins, leukotrienes). EPA also competes directly with AA for cyclooxygenase (COX-1/COX-2) and lipoxygenase enzymes, producing less inflammatory resolvins and protectins. DHA is highly concentrated in neuronal synapses and retinal photoreceptor outer segments, where it influences membrane curvature and protein recruitment. It promotes neurite outgrowth and synaptic plasticity by increasing membrane fluidity and activating transcription of brain-derived neurotrophic factor (BDNF). In the retina, DHA is critical for the conformational changes in rhodopsin during phototransduction.

The DHA, the other component of omega-3s gets the strongest concentration we have is in brain tissue and in the retina. As much as half of that retina is actually DHA. So when you're deficient in DHA, now your cell membranes, your brain and your retina get deficient and it changes a lot of signaling properties.

Also said
“The EPA, it enters into pathways that signal about inflammation. So, it helps reduce inflammation and therefore it is often quoted as being the heart support. It helps reduce heart disease because heart disease is basically an inflammatory disease.”— Clarifies the anti-inflammatory, not cholesterol-lowering, mechanism for heart health.

Consume organ meats (liver, heart, kidney) periodically as nature's multivitamin

WhatEat liver, heart, and kidney a couple of times a week or a few times a month to obtain extremely dense nutrients: active vitamin A (retinol), heme iron, CoQ10, collagen, elastin, selenium, zinc, and B vitamins.
WhenNot daily; liver (vitamin A risk) and kidney (extremely high selenium) should be eaten only a couple of times a week or a few times a month. Heart can be eaten more freely.
DoseLiver: moderation due to retinol toxicity; kidney: caution with excess selenium; heart: no strict limit. Ekberg warns against overconsumption of any single organ.
For whomEveryone without specific contraindications. Those with histamine intolerance may benefit from kidney (DAO). Pregnant women should be cautious about vitamin A from liver.
WhyLiver is nature's richest retinol source and loaded with B12, folate, B2, B6, heme iron, CoQ10. Heart has the highest CoQ10 (3–5x liver) and provides collagen/elastin for connective tissue repair. Kidney supplies extreme selenium (more than Brazil nuts) and the DAO enzyme that degrades histamine, potentially helping histamine intolerance. These organs deliver micronutrients in highly bioavailable forms that are difficult to match with muscle meat alone.
CaveatsLiver does not store toxins; it eliminates them — a common misconception. However, vitamin A can be toxic in excess, so limit liver consumption. Kidney has even more selenium than Brazil nuts; just 2-3 Brazil nuts reach the tolerable upper limit, so kidney should be eaten only occasionally. Don't eat the same organ daily.

Ekberg attacks the myths that liver is full of toxins because it's a detox organ. He clarifies that the liver processes and eliminates toxins, it doesn't hoard them. Liver is instead the richest food source of true, preformed vitamin A (retinol), which the body can use directly unlike beta-carotene from plants. Because retinol can accumulate and cause toxicity, frequency matters. Heart, being the hardest working muscle, is packed with mitochondria and thus CoQ10, plus unique proteins like collagen and elastin that support the body's structural repair. Kidney is highlighted for its selenium content — even higher than Brazil nuts, which themselves can cause selenium toxicity if eaten in excess — and for the enzyme diamine oxidase (DAO), which breaks down histamine. For the growing number of people struggling with histamine intolerance, kidney could be a natural source of DAO to mitigate reactions.

Mechanism

Retinol from liver is bound to retinol-binding protein and taken up by cells for vision, immune function, and gene transcription. Heme iron is absorbed via the heme carrier protein (HCP1) and is not inhibited by phytates like non-heme iron. CoQ10 from heart participates in the mitochondrial electron transport chain and acts as a lipid-soluble antioxidant. Selenium from kidney is incorporated into selenoproteins like glutathione peroxidase, thioredoxin reductase, and iodothyronine deiodinases. DAO enzyme degrades extracellular histamine in the gut, reducing systemic histamine burden.

We can think of these as nature's multivitamin. They're some of the most nutrientdense things that we can eat.

Also said
“Liver is the richest source of retinol that we know of which is active vitamin A and therefore we have to also keep in mind that vitamin A can be toxic. So if you eat tons of liver like every day that's probably not a good idea because you can get too much even of a good thing.”— Balances the strong endorsement with a clear toxicity warning.
“Kidney has the most selenium of any food. Brazil nuts are super high... But eating any more Brazil nuts than that can actually put you over the toxicity level. And kidney now has even more than that. So, it's also something that you don't want to eat every day.”— Provides a concrete comparison to alert about selenium overconsumption.

Eat grass-fed beef nose-to-tail: muscle, fat, and connective tissue

WhatConsume beef in its entirety — lean muscle cuts for protein and creatine, fatty cuts and bone marrow for saturated/monounsaturated fats and CLA, and slow-cooked connective tissues (oxtail, shank, bone broth) for collagen and elastin.
WhenAs a foundational dietary component; include fatty cuts and bone broth regularly, slow-cook tough cuts when desired.
DoseNo specific amount; beef is positioned as a 'foundational food' with high survival value that can be eaten frequently as part of a nose-to-tail approach.
For whomMost people, especially those seeking metabolic flexibility and tissue repair. Those with specific connective tissue or gut issues may benefit from extra collagen. Choose grass-fed when possible for a better fatty acid profile.
WhyMuscle meat provides complete protein, creatine, carnitine (fatty acid transport), zinc, B12, and heme iron. Fat provides stable fuel, saturated and monounsaturated fat in equal portions, CLA (a natural trans fat with anti-cancer properties), cholesterol for hormones, and fat-soluble vitamins A, D, K2. Connective tissue supplies collagen and glycosaminoglycans that rebuild the body's own connective tissue, including gut lining, joints, arteries, and skin. Ancestral diets used all parts for comprehensive nutrition.
CaveatsConventionally raised beef may have a less favorable omega-6 to omega-3 ratio and lower CLA; grass-fed is preferred but any beef is better than processed alternatives. Don't fear the fat — saturated fat is not the enemy.

He stresses that the modern diet has lost the connective tissue component entirely. By slow-cooking bones and tough cuts like oxtail or shank, the collagen gelatinizes and becomes bioavailable. That collagen provides the amino acids glycine, proline, and hydroxyproline needed for structural integrity throughout the body. He connects this directly to gut health: the intestinal lining is connective tissue; feeding it the raw materials supports repair and tight junction integrity. For arterial health, he argues that inflammation damages the endothelium, and eating the connective tissue building blocks helps repair the tissue, potentially mitigating heart disease. The fat is also rehabilitated: beef tallow is a historically valued fat, and the proportion of monounsaturated fat in beef is much higher than most people realize. CLA, a naturally occurring trans fat in ruminants, is described as a 'super nutrient' with proven anti-cancer effects, distinct from industrial hydrogenated trans fats.

Mechanism

Carnitine shuttles long-chain fatty acids into mitochondria for beta-oxidation. Creatine phosphate serves as a rapid ATP buffer in muscles. CLA modulates immune function and inhibits carcinogenesis through PPAR-gamma and NF-kB signaling. Collagen provides the essential amino acids for fibroblast synthesis of Type I/III collagen; the gut lining uses Type IV collagen and laminins for basement membrane integrity. Dietary glycine from collagen is also used for glutathione synthesis and bile acid conjugation, linking connective tissue to detoxification.

When we talk about beef, we need to think about that we're getting three different things. And most people when they talk about beef, they're just talking about the muscle meat, the lean meat. And we also need to think about fat. And we need to think about connective tissue because this is what our ancestors did.

Also said
“Then it contains something called CLA, which is conjugated linoleic acid, which some people refer to as a bad thing because it's a trans fat, but it has nothing to do with the trans fats in margarine or hydrogenated products. This is actually like a super nutrient. It's an antioxidant and it does us a lot of good. It's been clinically proven as an anti-cancer agent.”— Differentiates the beneficial natural CLA from harmful industrial trans fats.

Include leafy greens daily for magnesium and nitric oxide support

WhatEat leafy greens (romaine, green lettuce, arugula, kale, Swiss chard) regularly, using spinach cautiously if oxalate-sensitive, to supply magnesium (cofactor for 300+ enzymes), dietary nitrate that converts to nitric oxide (vasodilation), and prebiotic fiber.
WhenDaily, as salads or lightly cooked greens.
DoseNo specific amount; incorporate as a regular side dish.
For whomEveryone; those with magnesium deficiency symptoms (muscle cramps, poor sleep, stress) may particularly benefit. Spinach may be problematic for those with oxalate sensitivity or kidney stones, but most people can tolerate it.
WhyMagnesium is universally deficient due to soil depletion and refined carb consumption; it supports ATP production, DNA repair, and membrane potential stabilization (calming effect). Leafy greens are high in magnesium. Nitrate, when exposed to stomach acid, forms nitric oxide, a potent vasodilator that improves circulation.
CaveatsOxalate content in spinach can be an issue for individuals with leaky gut or low Oxalobacter bacteria; other greens are lower in oxalates. Magnesium supplementation may still be needed due to soil mineral depletion.

Ekberg highlights that magnesium is a 'universal deficiency,' asserting that modern soils no longer contain the mineral levels they once did, and that processed carbohydrates interfere with absorption. Magnesium's role in ATP (energy) production, DNA repair, and especially membrane potential (nerve cell stability) explains its reputation as calming. The dietary nitrate conversion depends on stomach acid; people on acid-suppressing drugs may compromise this pathway. Nitric oxide dilates blood vessels, enhancing nutrient and oxygen delivery. Combined with prebiotic fiber, leafy greens feed the gut as well.

Mechanism

Magnesium is a cofactor for ATP (Mg-ATP complex), required for >300 enzymatic reactions including kinases and DNA polymerases. It stabilizes neuronal membrane potential by blocking NMDA receptor calcium influx, reducing excitotoxicity. Dietary nitrate is reduced by oral bacteria to nitrite, then in the acidic stomach to nitric oxide (NO). NO activates soluble guanylyl cyclase in vascular smooth muscle, producing cGMP and causing relaxation (vasodilation).

Magnesium supports more than 300 enzyatic reactions and some of the most important ones are ATP making energy DNA repair depends on magnesium and also membrane potential. So your nervous system, your brain cells, your nerve cells, they have certain electrical potential and magnesium helps balance and regulate and and suppress that membrane potential a little bit so that these cells don't become overactive and erratic. That's why magnesium is often called calming.

Also said
“Magnesium is something that you would want to consider supplementing because most people are deficient due to soil depletions. The soil doesn't have nearly the amount of magnesium that it used to. And also refined carb consumption will interfere with the absorption of magnesium.”— Justifies supplement recommendation while also advocating for dietary sources.

What's new

Personal practice updates, fresh positions, predictions

5 items

two-genome-ecosystem-model

The human gut houses a microbiome with ~40 trillion bacteria containing 150 times more DNA than our human genome. This second genome must be fed separately with fiber, polyphenols, and resistant starch, while human cells need protein, fat, vitamins, and minerals.

Why this matters: Shifts the framing from 'healthy human diet' to 'feeding two interdependent ecosystems,' highlighting the microbiome as a larger biochemical factory that produces postbiotics essential for gut integrity and metabolic health.

Background

Conventional nutrition views all foods as nutrients absorbed by human cells; the importance of non‐digestible fiber and polyphenols is often relegated to a footnote about 'gut health' rather than positioned as a parallel nutritional requirement.

Ekberg explains that out of 30 trillion human body cells, 25 trillion are red blood cells with no nucleus, leaving only ~5 trillion metabolically active human cells. In the gut, the 40 trillion bacteria outnumber those by eight times and harbor 150 times more genetic diversity. This means the gut microbiome is a massive metabolic organ, producing short-chain fatty acids like butyrate that feed colonocytes, regulate tight junctions, and prevent LPS leakage. The two systems need separate feeding strategies: the human side craves protein, fat, vitamins, minerals; the gut side requires fermentable fibers and polyphenols that humans cannot digest. Ignoring this dual requirement means starving the bacterial ecosystem, which can lead to leaky gut, inflammation, and metabolic disease. He uses this to justify why the traditional food pyramid — which lumps all foods together and puts grains at the base — is fundamentally flawed.

So we want to start thinking of this that you have your human genome that your human DNA that's like your first genome but then in the gut you have a complete second genome that is actually much larger.

Also said
“So when it comes to humans we want to talk about feeding them protein, fat, vitamins and minerals. That's kind of the usual stuff that we talk about even though we get it backwards a lot. But with the gut, which is equally important to feed, we're talking about fermentable fiber that really does nothing for the human.”— Explicitly contrasts the two nutritional sets, showing why fiber and polyphenols are gut food, not human food.

endogenous-antioxidants-dwarf-dietary

Cruciferous vegetables contain sulforaphane, which activates the NRF2 pathway. This triggers the body's own antioxidant enzymes like catalase (neutralizes 6 million free radicals per minute) and superoxide dismutase, making dietary antioxidants like vitamin C negligible by comparison.

Why this matters: Challenges the deeply ingrained belief that eating antioxidant-rich fruits and vegetables is the primary way to combat oxidative stress, instead emphasizing an endogenous master switch that dwarfs any direct dietary source.

Background

The mainstream public has been told for decades that dietary antioxidants in fruits and vegetables protect cells. Ekberg argues that the real antioxidant power comes from the body's internally produced enzymes, and that cruciferous vegetables are not valued for their own antioxidants but for turning on these pathways.

Vitamin C, he notes, can donate only two electrons to neutralize one free radical before it must be recycled or excreted. In contrast, catalase, an enzyme encoded by genes and produced by our own cells, can neutralize 6 million free radicals per minute continuously. The NRF2 pathway is described as a master switch that, when activated by sulforaphane from broccoli sprouts or other crucifers, upregulates glutathione synthesis, catalase, and superoxide dismutase. This shift re-categorizes crucifers as 'gene activators' rather than just fiber + vitamin sources. He further ties this to the gut: the fiber in crucifers is fermented into butyrate, supporting gut lining, and sulforaphane also aids mucus formation, strengthening the gut barrier. This is a paradigm shift from antioxidant supplement thinking to epigenetically tapping the body's own defense systems.

Vitamin C, for example, it can donate two electrons and neutralize a free radical. Then it's done. Whereas for example this catalase it can it's an enzyme and it will neutralize six million free radicals per minute and keep going. So when we talk about antioxidants we really need to understand that we need to get them from inside the body.

Also said
“This is a chemical compound that activates what's called NRF2, which is kind of a master switch for your body's cleanup defenses.”— Confirms NRF2 as the master switch for antioxidant genes, making sulforaphane far more potent than any dietary antioxidant.

fermentation-as-predigestion-and-probiotic-factory

Fermenting dairy or vegetables not only adds live probiotic bacteria and yeasts but also predigests anti-nutrients like phytates and lectins, eliminates lactose in yogurt, and produces postbiotics such as butyrate that are critical for gut lining integrity.

Why this matters: Combines multiple underappreciated benefits of fermentation (anti-nutrient reduction, complete lactose removal in long-fermented yogurt, postbiotic generation) rather than viewing fermented foods merely as a source of 'good bacteria'.

Background

Many people are aware of probiotics in yogurt but often ignore the potential of homemade, long-fermented products that drastically reduce sugar content and increase bacterial diversity. Pickling is mistakenly equated with fermentation, but pickling preserves without live bacteria.

Ekberg distinguishes between the lactic acid fermentation (yogurt, kefir, sauerkraut, kimchi) that introduces colonizing and transiting bacteria like Lactobacillus and Bifidobacterium, and industrial pickling that uses vinegar and kills bacteria. He stresses that homemade yogurt run for 48–60 hours uses up virtually all lactose, making it tolerable even for lactose-intolerant individuals while greatly multiplying live bacteria. Vegetable ferments also supply prebiotic fiber and polyphenols that feed existing and incoming bacteria, which then produce butyrate. Butyrate feeds enterocytes, tightens gut junctions, and prevents lipopolysaccharide (LPS) leakage into the bloodstream — a key driver of systemic inflammation, anxiety, and depression. This positions fermented foods as a three-in-one: probiotics (live bugs), prebiotics (fiber/polyphenols), and postbiotics (butyrate and other compounds) — a comprehensive microbiome support system.

Personal experience

I run my yogurt for 48 to 60 hours and it gets much more sour and I get much more of the beneficial bacteria. Plus, they eat up all the lactose.

Fermentation is mankind's oldest form of preservation. And not just does it preserve it, but in case of yogurt and kefir, what they provide is probiotics. And that means that they have live bacterial species that can seed and diversify the bacterial flora that we have in our guts.

Also said
“Because in doing your own, you can let the machine run for much, much longer. I run my yogurt for 48 to 60 hours and it gets much more sour and I get much more of the beneficial bacteria.”— Details the practical method to maximize the bacterial load and eliminate lactose, a key personal protocol.
“The bacteria are making things like shortchain fatty acids. There's several different kinds, but the one that's most notable is buturic acid. And what this does is it feeds a lot of the cells in the gut. It feeds other beneficial bacteria but it's also fuel for the anterosytes for the cells that line our gut and keep that tight.”— Explains the mechanism of postbiotic butyrate maintaining gut barrier integrity.

everything-animal-has-value

Grass-fed beef and organ meats should be consumed nose-to-tail: muscle meat for protein and micronutrients, fat for saturated/monounsaturated fats and CLA, and connective tissues (bone broth, oxtail) for collagen and elastin that rebuild gut lining, joints, and skin.

Why this matters: Pushes back against the modern habit of eating only lean muscle meat and discarding fat and bones, arguing that the entire animal provides complementary nutrients with therapeutic properties (e.g., collagen for gut repair, CLA as an anti-cancer agent).

Background

Decades of fat-phobia and convenience have led people to trim fat and ignore bones, losing vital collagen, glycine, and fat-soluble vitamins. Ancestral cultures thrived on whole-animal consumption.

Beef fat, roughly half saturated and half monounsaturated, also provides conjugated linoleic acid (CLA), a trans fat naturally occurring in ruminants that is entirely different from industrial trans fats and has documented anti-cancer properties. Cholesterol from fat serves as a precursor for steroid hormones and fat-soluble vitamins A, D, and K2. Connective tissue, when slow-cooked (bone broth, oxtail, shank), yields collagen and other building blocks that directly support the body's own connective tissue: bone, cartilage, tendons, ligaments, arterial walls, and gut lining. Ekberg notes that damage to arterial walls from inflammation — a root cause of heart disease — can be mitigated by providing the structural substrates needed for repair. He frames this as ancestral wisdom discarded by modern food processing.

If we learn to cook and use all of it, we're getting so much more out of it.

Also said
“With the fat we get from fatty cuts, from eating beef tallow, and from taking advantage of the bone marrow, now we're getting saturated fats, which is energy. We're getting monounsaturated fats. And people don't realize that. They just hear saturated fat when it comes to beef. Well, we have about half of of in equal proportion saturated and monounsaturated.”— Corrects the misconception that beef fat is only saturated, emphasizing monounsaturated fats and CLA.
“If we turn the bones into bone broth, if we eat oxtail, if we eat shank or some other tougher tissues that we need to slow cook, now we can break down that connective tissue, make it very very tender and we get the collagen and we get lots of other things to reconstruct our own tissues.”— Practical advice for obtaining collagen from tough cuts and bones.

grains-are-just-calories

Grains, cereal, and starchy carbohydrates that form the base of the traditional food pyramid have no necessary nutrients for either human cells or the gut microbiome — they are just calories that disrupt metabolic health, especially in insulin-resistant individuals.

Why this matters: Directly contradicts dietary guidelines that position grains as essential, reducing them to empty fuel that impairs the very mechanisms real food supports (e.g., butyrate production, fat oxidation, stable blood glucose).

Background

For 50 years, public health messaging has championed grains as the foundation of a healthy diet. Ekberg argues that this is based on bad science and that the human body has no requirement for these foods.

He explains that grains contain no essential amino acids, no essential fatty acids, no vitamins or minerals that cannot be obtained in better forms from animal foods and vegetables. Their primary contribution is glucose, which requires insulin and can lead to blood sugar swings. In an insulin-resistant person, starchy foods exacerbate carbohydrate intolerance, raising triglycerides, inflammation, and fatty liver risk. By contrast, fat is a cleaner-burning fuel that does not provoke insulin spikes. He notes that the starch base interferes with most of the beneficial mechanisms he described, like NRF2 activation and gut barrier integrity. Even though some people can tolerate grains, they add no nutritional value; they are merely a cheap calorie source that have been erroneously promoted.

That base has very very few necessary components. There's really nothing in there that we have to have. It's just calories.

Also said
“In fact, the starches and the blood sugar swings resulting will disrupt and make worse most of the important mechanisms that we have discussed here that real food supports.”— Shows that starches actively undermine the benefits of the recommended foods.

Recommendations

Products, supplements, and tools mentioned in the episode

5 items

Yogurt maker (machine)

Tool

Ekberg recommends making yogurt at home with a machine, allowing fermentation for 48–60 hours to maximize live bacterial counts and eliminate lactose, producing a more sour, bacteria-dense product.

He presents the yogurt maker as a simple kitchen tool anyone can use. Buy a yogurt or kefir you like as a starter, add your own dairy, and let the machine run far longer than commercial processors do. This extended fermentation consumes the lactose and greatly increases the probiotic load, especially colonizing strains. It’s a practical, hands-on method for people who want to ensure they’re getting maximal gut benefit without added sugars or thickeners found in store-bought yogurts.

vs alternatives

Compared to commercial yogurt that is often fermented for only a few hours, pasteurized, and loaded with sugar or fruit syrups, homemade long-fermented yogurt contains a greater diversity and quantity of live bacteria and virtually zero lactose, making it both a more potent probiotic and suitable for those with lactose intolerance.

Personal experience

I run my yogurt for 48 to 60 hours and it gets much more sour and I get much more of the beneficial bacteria.

I would recommend that you make your own. do a little research, buy yourself a little yogurt machine.

Also said
“In doing your own, you can let the machine run for much, much longer. I run my yogurt for 48 to 60 hours and it gets much more sour and I get much more of the beneficial bacteria.”— Highlights the key advantage of the tool: extended fermentation time.
Find Yogurt

Magnesium supplement

Supplement

Due to widespread magnesium deficiency caused by soil depletion and interference from refined carbohydrates, Ekberg suggests considering magnesium supplementation in addition to eating leafy greens.

He discusses how magnesium supports over 300 enzymatic reactions including ATP production, DNA repair, and nervous system calming. Because modern soils contain far less magnesium and processed foods impair absorption, he states that dietary sources alone may not be sufficient for many people, making supplementation a practical consideration.

vs alternatives

While leafy greens are the best food source, the extent of soil mineral loss makes it difficult to meet needs solely through diet; supplementation can bridge the gap and directly address the deficiency.

Magnesium is something that you would want to consider supplementing because most people are deficient due to soil depletions.

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Wild-caught fatty fish (sardines, mackerel, herring, wild salmon)

Product

Ekberg identifies these as the best dietary sources of EPA and DHA, with low mercury contamination. Sardines are almost always wild-caught. He suggests choosing wild salmon over farm-raised when possible but notes that even farm-raised is better than processed alternatives.

The emphasis on wild-caught is driven by the higher omega-3 content and lower contaminant levels. Small fish like sardines and herring are low on the food chain, minimizing mercury. Wild salmon has a better fatty acid profile. He describes these fish as foundational because they provide the long-chain omega-3s that are difficult to obtain elsewhere.

vs alternatives

Compared to farm-raised salmon, wild-caught has a more favorable DHA/EPA ratio and fewer contaminants. Compared to fish oil supplements, whole fish also provides protein, selenium, and other co-nutrients. Compared to large predatory fish (tuna, swordfish), small fatty fish have low mercury risk.

The best sources are sardines, mackerel, salmon, and herring. These have the best quality of fat, the largest amounts of omega-3s, the EPA and the DHA, and they're also very low in contamination, very low in mercury primarily.

Also said
“The small fish like sardines are typically always wild caught. So that's good.”— Practical tip for effortlessly sourcing wild fish.
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Extra virgin olive oil

Product

Olive oil, especially extra virgin, contains oleocanthal, a compound that reduces inflammation by inhibiting COX-1 and COX-2 enzymes — the same mechanism as ibuprofen — without side effects. Used as a healthy fat source.

Olive oil is highlighted alongside avocados and olives as a low-carb, high-monounsaturated fat fruit oil that can be produced without heavy processing. The oleocanthal in olive oil acts as a natural anti-inflammatory. Ekberg notes the striking comparison to ibuprofen: both suppress COX enzymes, but olive oil does so without the gastrointestinal, renal, or cardiovascular side effects of chronic NSAID use. He recommends using extra virgin olive oil as a dietary staple to support fat-burning (via PPAR-alpha activation) and reduce inflammation.

vs alternatives

Compared to refined vegetable oils (seed oils) that are high in omega-6 and exposed to high heat and chemicals during extraction, extra virgin olive oil is cold-pressed, retains polyphenols, and has a demonstrated anti-inflammatory effect via oleocanthal. It is functional, not just a source of calories.

Olives and olive oil contain something called ooloanthl which will decrease the expression of something called cox one and cox 2 which are inflammatory messengers. So in other words, the olioanthal in olives will actually reduce inflammation. And very interestingly, this is the same mechanism as ibuprofen.

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Bone broth and slow-cooked connective tissue

Practice

To obtain collagen and other connective-tissue building blocks, Ekberg advises slow-cooking beef bones (bone broth), oxtail, shank, or other tough cuts. This practice releases gelatin and collagen that support gut lining, joints, skin, and arterial walls.

Modern eating habits discard bones and fat, missing the structural nutrients. By simmering bones and connective tissues for hours, the collagen hydrolyzes into gelatin and soluble peptides that are easily assimilated. Ekberg frames this as reclaiming ancestral nutrition: native peoples consumed the entire animal, and this supplied the raw material for their own connective tissue maintenance. He specifically ties it to gut repair, arterial health, and skin integrity. Bone broth is presented as an accessible kitchen practice with no special equipment required, just a pot and time.

vs alternatives

Compared to store-bought collagen powders or isolated peptides, homemade bone broth provides a complex matrix of collagen, gelatin, glucosamine, chondroitin, and minerals in a food matrix that may have greater bioavailability. It is also free from additives and cost-effective.

If we turn the bones into bone broth, if we eat oxtail, if we eat shank or some other tougher tissues that we need to slow cook, now we can break down that connective tissue, make it very very tender and we get the collagen and we get lots of other things to reconstruct our own tissues.

Find Bone

Notable quotes

Lines worth pulling out — contrarian, specific, or perfectly phrased

5 items
Dietary antioxidants don't even come close. They're not in the same universe of comparison. They're negligible in comparison. So vitamin C, for example, it can donate two electrons and neutralize a free radical. Then it's done. Whereas for example this catalase it can it's an enzyme and it will neutralize six million free radicals per minute and keep going.
Powerfully reframes the antioxidant conversation by quantifying the immense superiority of endogenous enzymes over dietary sources — a direct challenge to decades of marketing about antioxidant-rich foods.
Please please don't separate the egg the yolk from the white and I cry inside every time I see this little package in the store with egg whites. It is such a waste.
Emotionally loaded statement that emphasizes the yolk's nutritional value, memorable and personal.
That base has very very few necessary components. There's really nothing in there that we have to have. It's just calories.
Directly dismantles the foundation of the food pyramid (grains) as nutritionally empty, a bold and contrarian stance.
You have your human genome that your human DNA that's like your first genome but then in the gut you have a complete second genome that is actually much larger.
Memorable, paradigm-shifting metaphor that captures the entire dual-ecosystem thesis.
Magnesium is something that you would want to consider supplementing because most people are deficient due to soil depletions. The soil doesn't have nearly the amount of magnesium that it used to. And also refined carb consumption will interfere with the absorption of magnesium.
Names a widespread deficiency and links it to modern agricultural and dietary practices, making supplementation a rational choice.

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Topics covered

fermented-foodsprobioticsprebioticspostbioticsbutyrategut-microbiomesecond-genomeleaky-gutlpsnrf2sulforaphaneendogenous-antioxidantscatalaseglutathioneleafy-greensmagnesiumnitric-oxideberriesanthocyaninsakkermansia
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Educational summary of the cited expert source — not medical advice. Open the source recording linked above and consult a qualified physician before acting on any protocol.