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Episode
Your Baby's Metabolism is Being Decided Right Now | Jessie Inchauspé
~76 min
Episode Brief·YouTube

Your Baby's Metabolism is Being Decided Right Now | Jessie Inchauspé

Mark Hyman
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TL;DR

The four things you'd lose by not watching

4 items

TL;DR

The four things you'd lose by not watching

4 items
1

The speaker, Jessie Inchauspé, emphasizes that a mother's diet during pregnancy epigenetically programs the baby's health, influencing risks for conditions like diabetes, obesity, and neurodevelopmental issues.

2

She highlights four key nutritional pillars for pregnant women: blood sugar management, adequate choline intake (90% of pregnant moms are deficient), sufficient protein (70% are deficient), and omega-3 fatty acids (DHA).

3

Simple 'glucose hacks' like a protein-rich breakfast, eating sweets as dessert, moving after meals, and 'clothing carbs' (pairing them with protein/fat/fiber) can significantly reduce glucose spikes.

4

The book "Nine Months That Count Forever" provides practical guidance and recipes for pregnant women to optimize their diet, aiming to empower them without guilt.

Protocols

Concrete recipes — what, when, how much, and why

8 items

Protein-Rich Breakfast

WhatStart the day with a breakfast primarily composed of protein sources.
WhySets stable glucose levels for the day and helps manage cravings.

A protein-rich breakfast is crucial for setting stable glucose levels throughout the day, which in turn helps to prevent cravings and subsequent glucose spikes. The speaker suggests options like eggs, full-fat dairy, leftover meat or fish, or unsweetened protein powder. The goal is to build the meal around protein, avoiding sweet items (except whole fruit) as the base. This approach helps to mitigate the rapid absorption of sugars and starches that often characterize typical breakfast foods like muffins, bagels, and sugary yogurts.

No sugar first thing in the morning. You have a protein rich breakfast because sugar first thing in the morning is just gonna exacerbate those cravings, and you really don't wanna go there.

Also said
“So a breakfast built around protein. So good protein sources are, well, eggs. We talked about it. It can be some full fat dairy. It can be some leftover meat or fish from the night before.”— Provides specific examples of protein sources for breakfast.

Eat Sweets as Dessert

WhatConsume sweet foods immediately after a main meal, rather than on an empty stomach.
WhyReduces the glucose spike by leveraging the 'clothing' effect of the preceding meal's protein, fat, and fiber.

If you choose to eat something sweet, such as a doughnut or French toast, the speaker advises consuming it as dessert immediately after a full meal. This strategy helps to reduce the glucose spike because the protein, fat, and fiber from the main meal will slow down the absorption of sugar into the bloodstream. Eating sweets on an empty stomach leads to a much more rapid and significant glucose spike, which can trigger cravings and an energy crash. This hack allows for occasional treats while minimizing their negative metabolic impact.

So French toast or anything sweet, have it for dessert after a meal. Okay. At any point. Even if you're pregnant and you want a doughnut, have it after your lunch or after your dinner, not on an empty stomach.

Move After Eating

WhatEngage in physical activity, even for a short duration, after meals.
DoseEven 20 minutes of walking or 50 squats; calf raises are a convenient option if unable to move much.
WhyMuscles absorb glucose from the bloodstream, reducing post-meal glucose spikes.

Moving after eating is a simple yet effective way to mitigate post-meal glucose spikes. When you engage your muscles, they act as a sink for glucose, drawing it out of your bloodstream. Even a short walk of 20 minutes or performing 50 squats can be beneficial. For situations where extensive movement isn't possible, such as being stuffed on a couch, the speaker suggests calf raises. This involves going up and down on the balls of your feet, engaging the calf muscles to help soak up glucose. This practice helps to keep blood sugar levels more stable and prevents the sharp peaks and crashes associated with large meals.

Move after eating. After that big feast, if you had gone for an one hour walk, you would have seen a much smaller spike. Even twenty minutes.

Also said
“Even doing 50 squats in the living room for fun would have helped because as you move, your muscles absorb some of the glucose you just ate.”— Provides specific, easy-to-implement examples of movement.
“So you can do you can do calf raises. So if you were really stuffed after the meal on your couch, just do little calf push ups.”— Offers a practical solution for limited mobility after eating.

Put Clothing on Your Carbs

WhatAlways pair carbohydrates with protein, fat, or fiber.
WhySlows down sugar absorption, mitigating glucose spikes.

The principle of 'clothing your carbs' means never consuming carbohydrates in isolation. Instead, always pair them with protein, fat, or fiber. This combination creates a 'matrix' that slows down the digestion and absorption of sugars, preventing rapid glucose spikes. Examples include adding cheese to bread, almonds with a cookie, Greek yogurt with a doughnut, or chicken with pasta. The fiber, protein, and fat act as a buffer, similar to how Metamucil would slow the absorption of sugar from a can of Coke. This strategy helps to stabilize blood sugar and reduce the subsequent cravings that often follow a sharp glucose peak.

Put clothing on your carbs. So that means never eat your carbs naked. So if you want bread or pasta or rice or a cookie, don't have them naked. Add some protein.

Also said
“Cheese on a bread. Yeah. Like cheese on bread, like almonds with your cookie, like a Greek yogurt with the donut, like chicken with your pasta. Always add clothing.”— Provides concrete examples of how to 'clothe' carbs.

Start Meals with Vegetables

WhatConsume vegetables, especially fibrous ones, at the beginning of a meal.
WhyCreates a protective mesh in the intestine, slowing glucose absorption from subsequent carbohydrates.

Eating vegetables first at the beginning of a meal is a strategic hack to manage glucose spikes. The fiber from the vegetables forms a 'protective mesh' in the intestine. This mesh slows down the rate at which glucose from later-consumed carbohydrates enters the bloodstream. As a result, even if you eat the same pizza or pasta, the glucose spike will be smaller and more gradual, leading to a smaller crash and fewer cravings. This reordering of food intake allows individuals to enjoy carbohydrates without triggering the rapid blood sugar fluctuations that can negatively impact energy and mood.

And one more thing I would say is try to start your meals with vegetables because studies show that if you eat the vegetables first at the beginning of your meal, you're creating this sort of protective mesh in your intestine that slows down how quickly the glucose from carbs Fiber fiber. Bloodstream.

Increase Choline Intake During Pregnancy

WhatConsume adequate amounts of choline, ideally from food sources like eggs and organ meats, or supplement if necessary.
DoseMinimum 430 mg/day (bare minimum recommendation); 900 mg/day (shown to be more beneficial in studies). Four eggs provide 600 mg.
For whomPregnant women, especially those who are vegan (must supplement).
WhyCholine is essential for building the baby's brain cells and neurotransmitters, impacting neurodevelopment and IQ.
Caveats90% of pregnant moms are below the minimum recommended amount. Failure to provide enough choline can lead to irreparable brain damage.

Choline is identified as a critical nutrient for fetal brain development, responsible for building brain cells and neurotransmitters. The speaker notes that 90% of pregnant women do not meet the minimum recommended choline intake. While the bare minimum is 430 mg/day, studies suggest higher amounts (e.g., 900 mg/day) yield better outcomes, such as 10% faster reaction times in infants and improved behavioral scores at age three. Food sources like egg yolks (four eggs provide 600 mg) and organ meats (especially liver) are excellent. Vegans are particularly at risk of deficiency and should supplement. The American Association of Pediatrics warns that insufficient choline can cause irreparable brain damage. Despite its importance, this information is not widely communicated to pregnant women, even though it's added to baby formula.

Mechanism

Choline is a nutrient that directly builds brain cells and neurotransmitters, which are crucial for communication between brain cells. Studies show that adequate choline intake during pregnancy leads to faster reaction times in infants (linked to adult IQ) and better behavioral outcomes at age three. In animal studies, choline depletion severely affects brain development, leading to fewer neurons and premature cessation of brain development.

Personal experience

The speaker personally consumed four eggs daily during her pregnancy to ensure adequate choline intake, despite not always wanting to, because she understood its importance for her baby's brain development. She also humorously blamed her own mental health issues on her mother's low choline intake (Special K, sugar, orange juice) during her pregnancy.

Choline is a nutrient that builds your baby's brain cells and builds the neurotransmitters, meaning the way that your that his brain cells communicate with each other.

Also said
“And actually today, Mark, 90% of pregnant moms are below the minimum recommended amount of choline during pregnancy.”— Highlights the widespread deficiency.
“And in fact, the American Association of Pediatrics says that failure to provide choline during this critical time can lead to irreparable brain damage, even if there's more choline during the child's life afterwards.”— Emphasizes the severe consequences of deficiency.
“I mean, four eggs is six hundred milligrams. And you were saying nine hundred milligrams, and people don't really wanna eat four eggs. So know, but it's important. I didn't really wanna eat four eggs. I did it anyway because I was like, I need to get enough choline.”— Illustrates the practical challenge and commitment required for adequate intake.

Increase Protein Intake During Pregnancy

WhatConsciously increase protein consumption throughout pregnancy and breastfeeding.
DoseFirst trimester: 1.2 g/kg/day minimum. Second/Third trimester: 1.5 g/kg/day. Breastfeeding: 1.9 g/kg/day. (Example: 100g/day for the speaker).
WhyProtein is the fundamental building block for the baby's body (50% protein by weight excluding water) and the mother's health. Low protein intake epigenetically programs lower muscle mass in the baby.
Caveats70% of pregnant moms do not meet minimum protein requirements. As pregnancy progresses, stomach space decreases, making conscious protein focus even more important.

The speaker stresses the critical importance of protein during pregnancy, as the baby's body is 50% protein (excluding water). Current research indicates higher protein requirements than previously thought: 1.2 g/kg/day in the first trimester, 1.5 g/kg/day in the second and third, and 1.9 g/kg/day during breastfeeding. Alarmingly, 70% of pregnant women do not meet these minimums. Low maternal protein intake epigenetically programs the baby to have lower muscle mass, which is detrimental as muscle is considered the 'organ of longevity.' This programming can affect a child's ability to build muscle later in life, even with consistent exercise. The speaker advises making protein the central focus of meals and snacks, providing examples like four eggs for breakfast and a high-protein yogurt snack.

Mechanism

Protein is essential for building all tissues and systems in the baby's body, not just muscles (e.g., collagen, hormones, immune system). Animal studies show that low maternal protein intake, even with adequate calories, epigenetically programs the baby for lower muscle mass and a higher likelihood of disease later in life. This is because the baby's body adapts to a perceived protein-scarce environment by prioritizing essential organs over muscle development. Muscle is also crucial for the mother's longevity and metabolic health.

Personal experience

The speaker aimed for a minimum of 100 grams of protein daily during her pregnancy. She consumed four eggs for breakfast (30g) and developed a 'supercharged snack' of skyr yogurt with two scoops of grass-fed whey protein, berries, and other additions, providing 80 grams of protein. She emphasizes that she consciously measured and planned her protein intake.

So when you're building a baby, you're building a human body from scratch. Mhmm. And the human body is very high in protein. So protein is not just muscles.

Also said
“And today, seventy percent on average of moms are not hitting the minimum protein requirements That's incredible.”— Highlights the widespread deficiency in protein intake.
“If a mom has low protein intake during pregnancy, her baby is epigenetically programmed to have lower muscle mass.”— Explains the epigenetic consequence of low protein.
“So I would have four eggs in the morning, which is 30 grams, and then I would just have protein at every snack and every meal. I built it all around protein.”— Provides a personal example of how to achieve high protein intake.

Increase Omega-3 (DHA) Intake During Pregnancy

WhatConsume adequate amounts of DHA, primarily from fatty fish, and consider supplementation.
DoseMinimum 300 mg/day (equivalent to fish twice a week). Studies suggest 1.5 g/day can increase baby's IQ by 4 points.
WhyDHA is crucial for building the baby's brain cells and guiding their connections, impacting neurodevelopment and IQ.
Caveats68% of US adults are deficient in Vitamin D, and 95% have suboptimal levels, suggesting widespread omega-3 deficiency among pregnant women. Preterm birth rates have increased 30% since the 1980s, linked to omega-6/omega-3 imbalance.

DHA, an omega-3 fatty acid, is presented as another vital nutrient for fetal brain development, specifically for guiding the connections between brain cells. The recommended intake is 300 mg/day, typically achieved by eating fatty fish twice a week. However, studies indicate that higher doses, such as 1.5 g/day, can lead to measurable cognitive benefits, including a 4-point increase in a child's IQ at four years old. The speaker notes that DHA is added to baby formula in Europe but is not mandatory in the US, and pregnant women are often not advised to take it. Furthermore, the rise in preterm births in the US is linked to an imbalance of omega-6 to omega-3 fats, and DHA supplementation has been shown to reduce this risk. While concerns about heavy metals in fish exist, the benefits of omega-3s are said to outweigh the risks, especially from smaller, lower-trophic-level fish like sardines and anchovies. Supplementation is recommended to ensure adequate intake.

Mechanism

DHA is an omega-3 fat that specifically helps guide the long arms of brain cells to connect with each other. In lab experiments, neurons require DHA to form connections. Supplementing mothers with DHA has been shown to improve cognitive outcomes, such as a 4-point increase in a child's IQ at four years old. DHA also plays a role in reducing the risk of preterm birth, which has seen a significant increase in the US.

Personal experience

The speaker ate fish three times a week and supplemented with omega-3s during her pregnancy. She advises researching how to find a good, low-toxicity omega-3 supplement.

So DHA is an omega three fat that builds your baby's brain as well with choline. And in particular, what DHA does is that it helps guide the long arms of the brain cells that go and connect with each other.

Also said
“And in studies, when you supplement moms with about a gram and a half of DHA per day, scientists can measure a four point increase in the IQ of the baby at four years old.”— Quantifies the cognitive benefit of DHA supplementation.
“And one of the main links is the increase in omega six inflammatory fats and the decrease in omega three fat consumption. And in fact, and this is well established, when you supplement with omega threes, you reduce the risk of preterm birth.”— Connects DHA to reducing preterm birth risk.

What's new

Personal practice updates, fresh positions, predictions

5 items

Epigenetic Programming by Maternal Diet

0:00

A mother's diet during pregnancy doesn't just provide nutrients; it actively programs the baby's DNA, determining which genes are switched on or off, with long-term health consequences.

Why this matters: This concept challenges the traditional view of genetics as fixed and emphasizes the profound, controllable impact of maternal nutrition on a child's lifelong health trajectory.

Background

The speaker contrasts the idea of DNA being 'set at conception' with epigenetics, which refers to the regulation of gene expression. She uses the analogy of a seed and soil, where the mother is the soil nurturing the baby (seed).

The speaker explains that while a baby's DNA is determined at conception, the mother's diet during pregnancy influences epigenetics – the process by which genes are turned on or off. This 'programming' sends a 'postcard' to the baby, signaling what kind of world it will be born into. For example, a high-sugar diet can epigenetically activate fat storage genes, making the baby more vulnerable to weight gain and diabetes later in life, even if they eat the same diet as peers. This programming affects not just metabolic health but also neurodevelopment, with high glucose levels potentially leading to inflammation that impacts brain development.

At conception, your baby's DNA is set. But the epigenetics, which genes are switched on, which genes are silenced, that has to do with your diet during pregnancy.

Also said
“The food you eat sends a sort of like postcard to your baby, telling him what world he's gonna be born into.”— Illustrates the 'programming' concept with a vivid analogy.
“If a mom has low protein intake during pregnancy, her baby is epigenetically programmed to have lower muscle mass.”— Provides a specific example of epigenetic programming related to protein intake.

Placenta is Not a Filter

4:00

The placenta does not act as a perfect filter, allowing both beneficial and harmful substances, including high glucose levels and heavy metals, to pass from the mother to the baby.

Why this matters: This contradicts a common misconception that the placenta protects the baby from all maternal dietary choices, underscoring the direct impact of the mother's bloodstream on fetal development.

The speaker debunks the myth that the placenta is a perfect filter, stating that it 'trusts that whatever's in your bloodstream belongs in your baby's bloodstream.' This means that not only essential nutrients but also harmful substances like mercury and excess glucose can cross the placental barrier. High maternal glucose levels directly translate to high fetal glucose levels, forcing the baby to deal with inflammation and convert excess sugar into fat for protection. This direct transfer mechanism is crucial for understanding why maternal diet has such a profound impact on fetal health.

The placenta is not a filter, Mark. The placenta does not keep out all the bad and give only the good to your baby.

Also said
“The placenta kinda trusts that whatever's in your bloodstream belongs in your baby's bloodstream. Like mercury. Like mercury, but also like glucose.”— Emphasizes the direct transfer of both toxins and nutrients.

Miscarriage Experience and Normalization

6:00

The speaker shares her personal experience with a silent miscarriage, highlighting the emotional toll and the importance of normalizing conversations around miscarriage to reduce feelings of isolation and self-blame.

Why this matters: This personal anecdote provides a vulnerable and relatable perspective on a common yet often unspoken experience, aiming to support others going through similar challenges.

Personal experience

The speaker recounts her first pregnancy ending in a silent miscarriage at three months, where she carried a non-developing embryo for weeks without knowing. She describes it as the hardest emotional challenge of her life, leading to immense angst and depression. She felt isolated and blamed herself, even Googling celebrity miscarriages to feel less alone. She learned that miscarriages were common in her own family but had never been discussed. She shares this story in her book to help others feel less alone and understand that it's not their fault, even when doing 'everything right.'

I learned after I went through the journey, I learned that my mom had had miscarriages, and she had never told me. That my stepmom had, that my grandmother had, all of a sudden, started talking.

WHO Sugar Recommendation Controversy

18:00

The World Health Organization (WHO) initially aimed for a 5% added sugar intake guideline, but this was reportedly influenced and increased to 10% due to pressure from the food industry and figures like Donald Rumsfeld.

Why this matters: This reveals a historical instance of political and industry influence undermining public health recommendations regarding sugar consumption.

The speaker mentions a historical event where the WHO's efforts to lower the recommended daily intake of added sugar were allegedly thwarted by industry pressure. She states that Donald Rumsfeld, then working for President Bush, threatened to pull $400 million in funding from the WHO if they proceeded with a 5% added sugar guideline. As a result, the guideline was reportedly raised to 10%, a victory for the food industry. This anecdote highlights how external forces can compromise public health initiatives, leading to higher sugar consumption recommendations than scientifically advised.

Donald Rumsfeld, when he was working for president Bush, went to the WHO when they were trying to lower the sugar because he was in the food industry before. He said, we're gonna pull $400,000,000 of funding from the WHO if you do this.

UK Sugar Ration Study (1940s)

24:00

A natural experiment in the UK during the 1940s, where a sugar ration reduced daily intake by half, showed that babies born during this period had a 15% lower lifetime risk of diabetes.

Why this matters: This provides compelling real-world evidence of the direct, long-term impact of maternal sugar intake on a child's metabolic health.

The speaker cites a historical study from the UK during World War II. Due to rationing, the entire population, including pregnant women, saw their daily sugar intake drop from 80 grams to 40 grams for 13 years. Scientists later tracked 60,000 of these individuals born during or just after the ration. They found that those who developed in the womb during the sugar ration had a 15% lower lifetime risk of diabetes compared to those born just after the ration ended, when sugar intake increased again. This demonstrates a clear, measurable, and long-lasting benefit of reduced maternal sugar consumption on offspring health.

The babies who were developing in the womb during the sugar ration had fifteen percent less lifetime risk of diabetes compared to their peers who were born just after the ration ended, so when moms who ate more sugar.

Recommendations

Products, supplements, and tools mentioned in the episode

6 items

Nine Months That Count Forever: How the Pregnancy Diet Shapes Your Baby's Future

Book

The speaker's new book, inspired by her personal pregnancy journey and scientific research, provides practical guidance on optimal nutrition during pregnancy.

This book is the culmination of the speaker's personal experience with pregnancy and miscarriage, combined with her scientific background. It aims to educate pregnant women on the profound impact of their diet on their baby's epigenetic programming and long-term health. The book covers the four pillars of pregnancy nutrition (blood sugar management, choline, protein, and omega-3s) and offers practical suggestions, 'glucose hacks,' and recipes. It seeks to empower women with knowledge without inducing guilt, emphasizing that small steps can make a significant difference. The speaker hopes the book becomes 'irrelevant' quickly, meaning its core message is widely adopted by medical professionals.

Personal experience

The book was directly inspired by the speaker's own pregnancy and the realization that medical advice often lacked depth regarding nutritional impact on fetal development. She used her scientific research skills to uncover the data that forms the basis of the book.

Your book is nine months to count forever, and it's very personal for you. Mhmm. You had a baby. So take me back to when you were 31 and you had your first pregnancy and kinda walk me through the journey to how you got to this moment where you wanna tell the world that pregnant women should pay attention to what they eat.

Find Nine

Omega-3 Supplement

Supplement

Recommended for pregnant women to ensure adequate DHA intake, especially given widespread deficiencies and the importance for fetal brain development and reducing preterm birth risk.

But I do I do think most women should take an omega three supplement.

Find Omega-3

Vitamin D Supplement

Supplement

Recommended for pregnant women due to high rates of deficiency and suboptimal levels in the general population.

I do think they should take a vitamin D supplement.

Find Vitamin

Prenatal Vitamin with Folate

Supplement

Essential for pregnant women, specifically emphasizing the importance of the right type of folate (methylfolate).

They definitely need, obviously, a prenatal with the right types of folate. Exactly. Metastaticians.

Find Prenatal

Choline Supplement

Supplement

Recommended for pregnant women, especially vegans, to ensure adequate intake for fetal brain development, though food sources are preferred for absorption.

You can also take supplements of choline if you want. In a lot of, like, sort of forward cutting edge prenatal supplements, you'll find choline.

Find Choline

Grass-fed Whey Protein Powder

Supplement

A convenient and effective way to increase protein intake during pregnancy, particularly when appetite or stomach space is limited.

Personal experience

The speaker used two scoops of grass-fed whey in her daily 'supercharged snack' to achieve high protein intake.

And protein powder, like, whey protein is great if you're it's it's an incredibly good thing. I use go whey or regeneratively raise weight. I mean, it's you know, you wanna get clean stuff that's not full of crap.

Find Grass-fed

Notable quotes

Lines worth pulling out — contrarian, specific, or perfectly phrased

6 items
Your womb is not just an avid. It's more like your baby is a seed and you're the soil. And if you plant this seed in your driveway full of gravel, it's not gonna grow as strong and healthy as if you plant it in a nice piece of soil.
A powerful and memorable analogy that reframes pregnancy as an active co-creation process rather than passive incubation.
We're lying to moms. What happens during pregnancy is very important for the health of their baby.
A strong, provocative statement challenging conventional, often dismissive, advice given to pregnant women about diet.
I remember telling my husband that if feelings could kill, I feel like I would be dead.
A raw and impactful expression of the profound emotional pain experienced during miscarriage, highlighting its severity.
Muscle is the organ of longevity.
A concise and profound statement elevating the importance of muscle mass beyond aesthetics to a fundamental aspect of long-term health and survival.
You're literally writing a genetic expression software. You're the great programmer of the baby's DNA.
A striking metaphor that vividly conveys the active and powerful role of maternal diet in shaping a baby's genetic future.
I hope that this book becomes completely irrelevant very fast. Like, I hope everybody gets this. All doctors start talking about it, and this book is not useful anymore.
Expresses a genuine desire for widespread adoption of the book's principles, indicating a mission-driven approach rather than just commercial interest.

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Topics covered

epigeneticsmaternal dietfetal developmentplacenta functioncholine deficiencymiscarriage experienceglucose managementgestational diabetessugar consumptionprotein intakeomega-3 fatty acidsdha importanceneurodevelopmental issuesautism riskobesity programmingcravings managementglucose hacksprotein-rich breakfasteating sweets as dessertpost-meal movement
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