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Episode
Your Body Is Storing Toxins Right Now—Here's What Happens
~33 min
Episode Brief·YouTube

Your Body Is Storing Toxins Right Now—Here's What Happens

Mark Hyman
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TL;DR

The four things you'd lose by not watching

4 items

TL;DR

The four things you'd lose by not watching

4 items
1

Environmental toxins disrupt hormones, damage mitochondria, overwhelm detoxification pathways, and drive inflammation, leading to chronic diseases.

2

High-impact toxins include plastics (BPA, phthalates), chemicals in personal care/household products (parabens, synthetic fragrances), pesticides (glyphosate), heavy metals (mercury, lead), and indoor air pollutants (VOCs, mold, gas stoves).

3

Key actions to reduce toxic load involve avoiding heating food in plastic, filtering drinking water, using EWG-verified personal care products, eating organic (especially 'dirty dozen' items), and improving indoor air quality with air purifiers and natural materials.

4

Support your body's natural detoxification by consuming cruciferous vegetables, garlic, onions, turmeric, adequate protein, B vitamins, zinc, selenium, ensuring regular bowel movements with fiber, staying hydrated, and sweating through exercise or saunas.

Protocols

Concrete recipes — what, when, how much, and why

8 items

Reduce plastic exposure

WhatAvoid heating food in plastic, use glass or stainless steel containers, choose BPA-free cans, and minimize contact with receipts.
WhyPlastics contain endocrine disruptors like BPA and phthalates that mimic estrogen, cause insulin resistance, increase obesity risk, disrupt hormones, and contribute to various cancers.

Plastics are a major source of endocrine-disrupting chemicals such as BPA (bisphenol A) and phthalates. These chemicals are problematic because they act as xenoestrogens, interfering with the body's natural hormone balance, including estrogen, testosterone, and thyroid function. This disruption can lead to issues like reduced sperm count and motility, increased risk of weight gain, insulin resistance, and various hormone-related cancers (breast, prostate, ovarian, uterine). The speaker emphasizes that even 'safer' BPA-free plastics often contain similar problematic chemicals. Therefore, minimizing exposure is crucial, especially avoiding heating plastic as this can leach chemicals into food.

Many plastics contains chemicals like BPA and phalates. BPA stands for bisphenol A. These mimic estrogen in the body. They also can cause insulin resistance which are pretty bad. Increase risk of obesity.

Also said
“Never ever heat food in plastic. Never. Not a Tupperware. is plastic, saran wrap, no microwave food in plastic. Just forget about it.”— Highlights a critical and often overlooked source of exposure.
“Don't get the receipt or don't touch it if you can help it. That's a hard one, but uh do your best because those often have a lot of BPA in them.”— Identifies a less obvious source of BPA exposure.

Improve personal care and household product choices

WhatUse fragrance-free or essential oil-based products, and utilize resources like the Environmental Working Group's (EWG) Skin Deep app to identify safer options.
WhyMany personal care and household products contain hidden chemicals like parabens, phthalates, and synthetic fragrances that are absorbed through the skin, leading to hormone disruption, headaches, skin issues, and immune activation.

The skin is a highly permeable organ, and chemicals applied to it are readily absorbed into the bloodstream, similar to how medicinal patches (e.g., nitroglycerin, hormone, nicotine) deliver drugs. Products containing parabens, phthalates, synthetic fragrances, and formaldehyde-releasing preservatives can cause a range of issues from hormone disruption and migraines to skin irritation and immune system activation. The speaker's rule of thumb is 'if you wouldn't eat it, don't put it on your skin.' He advocates for using fewer products overall and choosing those made with natural, non-toxic ingredients. The EWG's Skin Deep app and website are recommended tools for vetting product safety, not just for skincare but also for household cleaners and food.

Personal experience

The speaker serves on the board of the Environmental Working Group (EWG) and uses their Skin Deep app. He personally uses Wina products and Tom's toothpaste, noting he has no affiliation but trusts their safety.

A simple rule of thumb I like to share is if it goes in your skin, it goes in your body. I mean, basically the rule is if you wouldn't eat it, don't put it on your skin.

Also said
“I'm on the board of the environmental working group or EWG. There's a great app called Skin Deep. You go on the website, you can use the app and you can scan products. You can search products and you can see how do they stack up.”— Provides a specific, actionable resource for product evaluation.
“I use uh Wina products. I'll use Tom's toothpaste. I use just products I know are safer or better. I don't have any affiliation with them.”— Gives examples of products he personally uses and trusts.

Minimize pesticide exposure through food and environment

WhatPrioritize organic produce, especially items on the 'dirty dozen' list, thoroughly wash all produce, and avoid using toxic lawn chemicals.
WhyPesticides like glyphosate are widespread, damage the gut microbiome, impair detoxification enzymes, increase inflammation, and are linked to cancer and transgenerational epigenetic effects.

Glyphosate, the most common herbicide, is used on 70% of crops and is a significant source of toxic exposure. It's found in non-organic produce, grains, processed foods, and is also used on lawns. Glyphosate is particularly concerning because it harms the gut microbiome, interferes with the body's natural detoxification enzymes, and drives systemic inflammation. It has been linked to digestive issues, immune problems, and cancer, with billions of dollars in lawsuits against its manufacturer. The speaker also highlights its use as a desiccant on wheat at harvest, meaning it's present in many grain products. The Environmental Working Group's 'dirty dozen' and 'clean 15' lists are recommended for making informed organic purchasing decisions, allowing consumers to prioritize which produce to buy organic to maximize impact while managing cost.

Pesticides and herbicides are real big deals, especially glyphosate, which is the most common herbicide is used on 70% of all crops. It's one of the most common ways people are exposed to environmental toxins through food.

Also said
“There's more glyphosate in terms of pure quantity in Cheerios than there is some of the vitamins and minerals that they list on the label.”— Illustrates the surprising presence of glyphosate in common processed foods.
“Do your best to eat organic when you can. Again, the Environmental Working Group has a great list of the dirty dozen. Uh, and the clean 15.”— Provides specific, actionable guidance for organic food choices.

Reduce heavy metal exposure

WhatBe mindful of fish consumption (especially large predatory fish), test old homes for lead, avoid cigarette smoke, and filter drinking water.
WhyHeavy metals like mercury, lead, cadmium, and arsenic are neurotoxic, causing brain fog, fatigue, cognitive impairment, and developmental issues, particularly in children.

Heavy metals, though naturally occurring, are now widely dispersed due to industrial activities like coal burning. They accumulate in the food chain, particularly in large predatory fish (shark, swordfish, tuna). Exposure also comes from old plumbing and paint in pre-lead regulation homes, and cigarette smoke. These metals are highly toxic, especially to the nervous system, leading to symptoms like brain fog, chronic fatigue, cognitive impairment, and sleep issues. In children, heavy metals are implicated in neurodevelopmental disorders. Filtering drinking water, ideally with reverse osmosis (while ensuring mineral replacement), is crucial due to the presence of numerous chemicals and metals in tap water. Testing older homes for lead is also advised.

Personal experience

The speaker personally experienced severe mercury poisoning, which led to chronic fatigue syndrome, brain fog, cognitive impairment, muscular damage, and neurological damage, making him an 'expert' in the field.

These metals can cause havoc. I experienced it personally because I had mercury poisoning. They affect your nervous system. They cause brain fog, fatigue. I developed chronic fatigue syndrome from it. Cognitive impairment, sleep issues.

Also said
“If you eat fish like tuna or swordfish or almost any fish unless really little little fish or certain generally farmed fish and I like ctopia fish don't relationship with them but they're great they they have really great sources. There's some heavy metals that are much lower than other fish and you have to be careful because it concentrates up the food chain.”— Offers specific advice on fish consumption and mentions a brand he trusts for lower heavy metal fish.
“I have a reverse osmosis filter at home. As long as you're taking a multivitamin mineral or you're replacing minerals, having electrolytes, you're fine. really important because there's just so many not just metals but also other pesticides and chemicals and all kinds of things in water.”— Recommends a specific water filtration method and important caveat for its use.

Improve indoor air quality

WhatOpen windows regularly, choose furniture made with natural materials (solid wood, low/non-VOC finishes), use HEPA/activated carbon air purifiers, and check for mold.
WhyIndoor air can be more polluted than outdoor air due to VOCs from furniture, building materials, mold, cleaning sprays, and gas stoves, leading to asthma, brain fog, headaches, and immune dysfunction.

Indoor air pollution is a significant and often overlooked source of toxic exposure, as many people spend most of their time indoors. Volatile Organic Compounds (VOCs) off-gas from new furniture, glues, adhesives, paints, and engineered wood products. Mold, often hidden, can also contribute to poor air quality, especially if a musty smell is present. Cleaning products and gas stoves are additional sources of indoor pollutants. These can cause a range of health issues including asthma, brain fog, headaches, and immune dysregulation. The speaker emphasizes the importance of ventilation (opening windows), selecting natural and low-VOC materials for home furnishings, and using high-quality air purifiers with HEPA and activated carbon filters to remove both particulate matter and chemical gases.

Personal experience

The speaker recounts buying a Tempur-Pedic mattress that 'stank' from off-gassing chemicals, leading him to later choose a natural latex mattress from Essentia. He also has air filters in his bedroom and other frequently used rooms.

Indoor air can be more polluted than outdoor air because you get VOCC's from furniture from building materials from mold, cleaning sprays, gas ovens and poor indoor air quality can cause all sorts of stuff. Asthma, brain fog, headaches, immune disregulation.

Also said
“I have a mattress that is great mattress. It's a latex mattress that's made from natural materials. It's from Essentia. It's kind of like a Tempropitic. I did have a Tempropitic once and when I bought it, I was like, 'Oh my god, this thing just stinks.'”— Illustrates a personal experience with off-gassing furniture and a safer alternative.
“Have an air purifier. I have an air filter in my in my bedroom and in all the rooms I spend the most time in the house. Uh you want a HEPA or ultra heepa air purifier with activated carbon.”— Provides specific recommendations for air purification technology.

Support liver detoxification

WhatConsume cruciferous vegetables (broccoli, kale, Brussels sprouts), garlic, onions, turmeric, adequate protein (for amino acids like glycine), B vitamins, zinc, and selenium. Avoid alcohol.
WhyThe liver is central to detoxification, requiring specific nutrients and compounds to support its biochemical pathways, which can be overwhelmed by toxic load.
Mechanism

The liver's detoxification pathways involve a series of biochemical steps that convert toxins into water-soluble compounds for excretion. These processes require specific cofactors: amino acids (especially glycine, a precursor to glutathione, the body's main detoxifying compound), B vitamins (crucial for methylation, a key detox step), and minerals like zinc and selenium. Alcohol is a direct liver toxin, increasing its burden.

Your liver is really important and there's great foods that's upbreaking your body's own detoxification pathways. My favorite of the broccoli family, you know, broccoli, collards, kale, cabbage, Brussels sprouts, etc. Also, garlic and onions are great. Certain herbs and spices are great like turmeric.

Also said
“Protein, yes, protein is really important. And if you look at a lot of the pathways, and there's a whole series of biochemical steps that happen in your liver when you detoxify things, requires amino acids, especially glycine, because it's part of making glutathione.”— Explains the role of protein and specific amino acids in liver detox.
“B vitamins really important. Methylation is a key step. B12, folate, B6, but all the B vitamins, uh, really important. Zinc, selenium, also minerals, really important. And alcohol. Alcohol is just a liver toxin. So, I would encourage you to to not drink if you can.”— Lists other essential nutrients and a key substance to avoid for liver health.

Optimize gut elimination

WhatEnsure regular bowel movements (ideally 1-3 times daily) by consuming plenty of fiber and fermented foods, and maintaining a healthy gut microbiome.
WhyAfter liver metabolism, toxins are excreted into the gut via bile; if bowel movements are infrequent, toxins can be reabsorbed, increasing toxic load.
Mechanism

The liver processes toxins, making them water-soluble, and then excretes them into the bile, which is released into the intestinal tract. For these toxins to be permanently removed from the body, they must be eliminated through feces. If an individual is constipated or has infrequent bowel movements, these processed toxins remain in the gut for longer, increasing the chance of reabsorption back into the bloodstream. Fiber is crucial because it adds bulk to stool, promotes regular bowel movements, and helps bind to toxins, facilitating their excretion. A healthy gut microbiome also supports this process.

Personal experience

The speaker recounts a patient who considered once-a-week bowel movements 'regular for me,' highlighting a common misconception about healthy bowel frequency.

The next is your gut. It's how once the toxins get metabolized by the liver, they get excreted in the bile, they get dumped into your intestinal tract and they have to get out. Now, if you're constipated or you're sluggish, you're not having regular bowel movements. Guess what? You are going to recirculate those and they're going to get reabsorbed.

Also said
“I had a patient. I said, 'You have regular bowel movements?' She says, 'Yeah, I regular bowel movements.' I said, 'Well, how often do you go?' She goes, 'Once a week.' I'm like, 'What do you mean that's not regular?' She goes, 'Yeah, it's regular for me. I go every week.' Really? The idea here is that you should probably go at least once, if not two to three times a day.”— Illustrates a common misunderstanding of healthy bowel frequency and provides a target.
“Fiber is a way to do that. And there's lots of different kinds of fiber. Fermented foods are great. Keeping your microbiome healthy is really important. Preventing a leaky gut, really important.”— Lists specific dietary components that support gut elimination.

Support kidney and skin elimination

WhatStay well-hydrated (at least half your body weight in ounces daily) with electrolytes and minerals, and promote sweating through saunas or exercise.
WhyKidneys filter toxins from the blood for urinary excretion, and the skin eliminates toxins through sweat; both require adequate hydration and support.
Mechanism

The kidneys are vital for filtering waste products and toxins from the blood, which are then excreted in urine. Adequate hydration is essential for optimal kidney function, as water helps flush these substances out. Electrolytes and minerals support the kidneys' ability to maintain fluid balance and filter efficiently. Sweating, whether through exercise or saunas, is another important route for toxin elimination through the skin. The breath also plays a role in expelling certain toxins, including carbon dioxide.

Hydration, that's another thing. Kidneys, really important. Also, you metabolize toxins, they have to get out. So, you got to drink, make sure you're drinking a lot of fluids. Uh, at least half your body weight in ounces every day. Electrolytes, minerals, all help your kidneys work. Sweat, persspire. That's the other one, right? Sweating. So, saunas are great. Exercise is great.

What's new

Personal practice updates, fresh positions, predictions

4 items

Chronic disease and total toxic load

0:20

Chronic disease is not solely due to diet or genetics but significantly influenced by the cumulative 'total toxic load' from daily chemical exposures, a concept often overlooked in conventional medical education.

Why this matters: This challenges the conventional medical view by highlighting an under-recognized factor in chronic disease, suggesting a broader perspective beyond genetics and diet.

Background

The speaker notes that in medical school, he learned about acute toxicity but 'zip, zero, nada' about the total toxic burden or how to diagnose/treat it. This indicates a gap in traditional medical training regarding environmental health.

Personal experience

The speaker shares his personal experience living in China, where he was exposed to severe air pollution from raw coal, leading to mercury poisoning. This firsthand experience made him an 'expert' in the field.

Chronic disease isn't just about food or your genes. It's about your total toxic load. Something I never learned about in medical school. Like zip, zero, nada.

Transgenerational epigenetic effects of glyphosate

14:30

Glyphosate exposure can cause transgenerational epigenetic effects, meaning the damage can be passed down through generations, affecting fertility, hormones, and disease risk in offspring not directly exposed.

Why this matters: This reveals a profound and long-lasting impact of a common herbicide, extending beyond the exposed individual to future generations, which is a significant concern.

The speaker cites a recent study where grandmother mice exposed to glyphosate showed significant damage in their grand-babies, including issues with fertility, hormones, increased cancer risk, and kidney problems. This suggests that the effects of glyphosate are not limited to the individual exposed but can alter genetic expression in subsequent generations, leading to inherited health problems. This mechanism, known as epigenetics, indicates that environmental exposures can leave a lasting mark on the germline, impacting the health trajectory of a lineage.

I read a study recently where there were transgenerational effects, epigenetic effects. So the grandmother mouse had glyphosate exposure. The grandb babies had all kinds of damage to fertility, to hormones, cancer risk, kidney issues.

Also said
“It's again on 70% of all products. It's one of the most toxic compounds out there. It should be banned.”— Emphasizes the widespread nature of the problem and the speaker's strong opinion on its regulation.

Indoor air quality and productivity

19:00

Investing in high-quality indoor air can significantly boost employee productivity, as demonstrated by a $2 billion building in New York City and the speaker's own functional medicine center.

Why this matters: This highlights a practical, business-oriented benefit of addressing indoor air pollution, moving beyond just health concerns to economic advantages.

Personal experience

The speaker recounts an architect patient who worked on a $2 billion Bank of America building in NYC, which invested heavily in superior indoor air quality. The architect reported significantly higher employee productivity as a result. The speaker applied this lesson when building the functional medicine center at Cleveland Clinic, insisting on strict environmental standards to avoid off-gassing chemicals and ensure proper air/water filtration. He observed that people felt better and less tired in that space.

And he said because the productivity was so much higher in their employees. When we built our center for functional medicine at Cleveland Clinic, I insisted that we hire an environmental firm and we follow strict environmental standards for the products in there.

Detoxification as a scientific therapy

23:40

Contrary to some medical opinions, detoxification is a highly scientific and evidence-backed therapy, with extensive literature supporting its mechanisms and benefits.

Why this matters: This directly refutes a common skeptical stance within the medical community, asserting the scientific validity of detoxification when properly understood.

The speaker challenges the notion that detoxification is 'stupid and unscientific,' arguing that this view stems from a lack of engagement with the existing scientific literature. He states that he has studied this extensively for his own health and his patients, confirming that there is a 'real system' for detoxification and many ways to support it. He implies that the problem is not a lack of evidence, but rather a failure of some medical professionals to review the available evidence.

A lot of doctors go, well, you know, your body just does it. You don't have to worry about it. It's like no big deal. Like, you can't do anything. And detoxification is as a therapy is just stupid and unscientific. Well, that is absolutely wrong. It's extremely scientific and if you look at the literature, you'll find it.

Recommendations

Products, supplements, and tools mentioned in the episode

2 items

Essentia mattress

Product

A latex mattress made from natural materials, recommended as a non-toxic alternative to synthetic mattresses that off-gas chemicals.

vs alternatives

Compared to a Tempur-Pedic mattress, which the speaker found to have a strong chemical odor from off-gassing, the Essentia mattress is made from natural latex, avoiding synthetic chemicals.

Personal experience

The speaker previously bought a Tempur-Pedic mattress that 'stank' from off-gassing chemicals. He later switched to an Essentia latex mattress made from natural materials, finding it to be a much better, non-toxic option.

For example, I have a mattress that is great mattress. It's a latex mattress that's made from natural materials. It's from Essentia. It's kind of like a Tempropitic. I did have a Tempropitic once and when I bought it, I was like, 'Oh my god, this thing just stinks.'

Find Essentia

HEPA or ultra HEPA air purifier with activated carbon

Tool

An air filtration device recommended for improving indoor air quality by removing volatile organic compounds (VOCs) and other pollutants.

Air purifiers equipped with HEPA (High-Efficiency Particulate Air) or ultra HEPA filters are crucial for removing airborne particles like mold spores, dust, and allergens. The addition of activated carbon is essential for adsorbing gaseous pollutants, including volatile organic compounds (VOCs) that off-gas from furniture, building materials, and cleaning products. The speaker emphasizes placing these purifiers in bedrooms and other rooms where significant time is spent to maximize their effectiveness in reducing exposure to indoor air toxins.

Personal experience

The speaker has air filters in his bedroom and all rooms where he spends the most time in his house.

Have an air purifier. I have an air filter in my in my bedroom and in all the rooms I spend the most time in the house. Uh you want a HEPA or ultra heepa air purifier with activated carbon.

Find HEPA
Disclosed sponsorships3speaker disclosed

Function Health

Service Sponsored · disclosed

A service offering over 160 lab tests for $365 a year, allowing individuals to track vitamin D, hormone balance, inflammation, and other health markers.

DisclosureThis episode is brought to you by Functionhealth.

Function Health provides comprehensive lab testing, including over 160 different markers, for an annual fee of $365. This service is positioned as a way to proactively monitor various aspects of health, such as vitamin D levels, hormone balance, and inflammation patterns, throughout the year. The speaker emphasizes that many biological changes happen 'quietly' and are not felt or seen without data, making regular testing valuable for understanding and responding to the body's 'seasons' or shifts. The annual cost is highlighted as being equivalent to 'literally a dollar a day.'

This episode is brought to you by Functionhealth, empowering you to live a 100 healthy years with over 160 lab tests at just $365 a year. Sign up today at functionhealth.com/mark and use the code mark2026 to get $50 towards your membership.

Find Function

Skin Deep app / EWG website

Tool Sponsored · disclosed

An app and website by the Environmental Working Group (EWG) that allows users to scan or search products (skincare, household cleaners, food) to see their safety ratings and chemical content.

DisclosureI'm on the board of the environmental working group or EWG.

The Skin Deep app and the Environmental Working Group (EWG) website are recommended as crucial tools for consumers to assess the safety of various products. The EWG evaluates products not just for skincare but also for household cleaning and food, providing ratings and information on potential toxic ingredients. The speaker, being on the board of the EWG, highlights its comprehensive approach to identifying and rating products based on their chemical composition and potential health impacts. This resource empowers individuals to make informed choices to reduce their exposure to hidden toxins in everyday items.

I'm on the board of the environmental working group or EWG. There's a great app called Skin Deep. You go on the website, you can use the app and you can scan products. You can search products and you can see how do they stack up.

Find Skin

Using EWG's 'Dirty Dozen' and 'Clean Fifteen' lists

Practice Sponsored · disclosed

Lists from the Environmental Working Group (EWG) that guide consumers on which produce items are most important to buy organic ('dirty dozen') and which are generally safe to buy conventional ('clean fifteen').

Disclosurethe Environmental Working Group has a great list of the dirty dozen. Uh, and the clean 15.

The 'dirty dozen' and 'clean fifteen' lists, compiled by the Environmental Working Group, are practical tools for navigating organic produce purchases. The 'dirty dozen' identifies fruits and vegetables that tend to have the highest pesticide residues when conventionally grown, making them a priority for organic buying (e.g., strawberries, celery). Conversely, the 'clean fifteen' lists produce with the lowest pesticide residues, which can often be safely purchased conventionally (e.g., bananas). This strategy helps consumers reduce their pesticide exposure effectively without needing to buy everything organic, thus managing costs and making healthier eating more accessible.

Do your best to eat organic when you can. Again, the Environmental Working Group has a great list of the dirty dozen. Uh, and the clean 15. Here's the dirty dozen. For example, strawberries, you never want to eat if they're not organic. Whereas, if it's a banana, it's fine.

Find Using

Notable quotes

Lines worth pulling out — contrarian, specific, or perfectly phrased

5 items
This isn't about fear and making you scared. It's not about being perfect and every toxin. It's about understanding what you need to do, have some clarity, what you should prioritize, and what you actually can control so you don't have to be ongoingly dumping toxins in your system.
Sets a pragmatic and empowering tone, emphasizing actionable control over fear or perfectionism.
Your body already knows how to detoxify. You just have to help it. The problem isn't that your detox systems are broken. You're just a little overwhelmed.
Offers a reassuring perspective on the body's innate capabilities, reframing the issue as one of support rather than inherent failure.
If you wouldn't eat it, don't put it on your skin.
A simple, memorable, and impactful rule of thumb for evaluating personal care products.
There's more glyphosate in terms of pure quantity in Cheerios than there is some of the vitamins and minerals that they list on the label.
A shocking and specific comparison that highlights the pervasive and hidden nature of glyphosate in common foods.
The idea here is that you should probably go at least once, if not two to three times a day. And I know it sounds crazy, but if you look at the studies by Burket and others from from England who studied a lot of the the cancer risks, for example, in in Africa, they found that if you were a hunter gather in Africa, your stool weight was about 2 lbs a day. If you were an urban dweller, same ethnicity, same genetics, it was about 4 ounces.
Challenges common perceptions of healthy bowel frequency with a surprising, research-backed historical comparison.

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Topics covered

total toxic loadenvironmental toxinshormone disruptorsmitochondrial damagedetoxification pathwaysinflammationobesogensneurotoxicityleaky gutplasticsbpaphthalatespersonal care productsparabenssynthetic fragrancesewg skin deeppesticidesglyphosatedirty dozenclean fifteen
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